FPGEE for National Association of Boards of Pharmacy (NABP) Practice Exam 2025 - Free NABP Practice Questions and Study Guide

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What is the pharmacological strategy used to enhance the effect of lopinavir?

Concurrent administration of tenofovir

Combination with ritonavir

The pharmacological strategy used to enhance the effect of lopinavir involves its combination with ritonavir. Ritonavir is a protease inhibitor that primarily serves as a booster for other protease inhibitors, such as lopinavir. When combined, ritonavir inhibits the CYP3A4 enzyme, which metabolizes lopinavir. This inhibition leads to higher plasma concentrations of lopinavir, thereby enhancing its antiviral effectiveness without the need for significantly increasing the dose of lopinavir itself.

This strategy is particularly valuable in the treatment of HIV, as it allows for more effective suppression of viral load while also optimizing the dosing regimens and minimizing potential side effects related to higher doses of the active drug alone. The synergy between these two medications demonstrates an important approach in antiretroviral therapy, maximizing therapeutic effects while ensuring patient safety.

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Using higher doses of lopinavir

Adding acyclovir

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