FPGEE for National Association of Boards of Pharmacy (NABP) Practice Exam 2025 - Free NABP Practice Questions and Study Guide

Mesna is a chemoprotective agent that is specifically used to prevent hemorrhagic cystitis, a potential side effect associated with the use of nitrogen mustards, such as cyclophosphamide and ifosfamide. These alkylating agents can lead to the formation of toxic metabolites that irritate the bladder and lead to inflammation and bleeding, resulting in hemorrhagic cystitis.

When mesna is administered alongside nitrogen mustards, it acts by binding to these toxic metabolites, thus preventing their harmful effects on the bladder tissue. Mesna is often given as an intravenous infusion or orally, and its role is crucial in reducing the risk of this painful and potentially serious complication.

In contrast, nephrotoxicity, cardiotoxicity, and dermatitis are not the primary concerns addressed by mesna. Nephrotoxicity can occur with some chemotherapeutic agents, but it is not specifically mitigated by mesna. Similarly, cardiotoxicity is not a typical concern with nitrogen mustards; it is more relevant to drugs like doxorubicin. Dermatitis is also not directly associated with nitrogen mustards in the context of mesna usage, as mesna's action is focused specifically on the urinary system and the preventive aspect of bladder