FPGEE for National Association of Boards of Pharmacy (NABP) Practice Exam 2025 - Free NABP Practice Questions and Study Guide

The involvement of specific receptor types in mediating nausea and vomiting is well-documented in pharmacology and neurobiology. The correct choice includes histamine, dopamine, and serotonin receptors, each of which plays a distinct role in the vomiting reflex.

Histamine receptors, particularly the H1 subtype, are linked to the vestibular system's input and can trigger nausea and vomiting, especially motion-induced forms. This is why anti-histamines are often used for treating motion sickness.

Dopamine receptors, especially the D2 subtype, are located in the chemoreceptor trigger zone of the brain and are involved in the emetic response. Dopamine antagonists can effectively reduce nausea and vomiting caused by various stimuli, including chemotherapy and post-surgical states.

Serotonin receptors, particularly the 5-HT3 subtype, are critical in mediating signals from the gastrointestinal tract to the central nervous system. Serotonin release from the bowel can stimulate these receptors, leading to nausea and vomiting, which is why serotonin antagonists are widely used in the management of chemotherapy-induced nausea.

The other options contain receptor types that are not primarily associated with the classic pathways of nausea and vomiting. For example, while glutamate is involved in various neurological processes, it does not