FPGEE for National Association of Boards of Pharmacy (NABP) Practice Exam 2025 - Free NABP Practice Questions and Study Guide

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What is the mechanism of action of Tamoxifen?

Inhibits aromatase enzyme

Blocks estrogen in breast tissue

Tamoxifen's mechanism of action centers on its role as a selective estrogen receptor modulator (SERM). It primarily acts by binding to estrogen receptors, particularly in breast tissue, which interferes with estrogen's ability to promote the growth of estrogen-dependent tumors. By blocking the action of estrogen in these tissues, Tamoxifen reduces the proliferative effects that estrogen would have on breast cancer cells.

This targeted inhibition is crucial for the treatment of hormone receptor-positive breast cancer, where the growth of the cancer is driven by estrogen. By effectively blocking the estrogen receptor, Tamoxifen can help to slow down or even reverse the progression of the disease. The other options relate to different mechanisms or drugs that do not apply to Tamoxifen’s role in cancer therapy.

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Acts as a glucocorticoid

Stimulates androgen production

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