FPGEE for National Association of Boards of Pharmacy (NABP) Practice Exam 2026 - Free NABP Practice Questions and Study Guide

First- and second-generation progestins are primarily associated with more androgenic properties. These types of progestins tend to have effects that are similar to androgens, which can lead to side effects such as acne, hirsutism, and other manifestations of increased testosterone activity. This is particularly notable in first-generation progestins, which were developed as modifications of testosterone. Over time, subsequent generations of progestins have been designed to minimize these androgenic effects, but first- and second-generation progestins are still recognized for their tendency to exhibit these properties, influencing their clinical use and the side effects that may arise from their medication regimens.