FPGEE for National Association of Boards of Pharmacy (NABP) Practice Exam 2025 - Free NABP Practice Questions and Study Guide

Surfactants play a crucial role in creams primarily by acting as emulsifying agents. They are molecules that reduce the surface tension between two immiscible phases, such as oil and water. This ability is particularly important in creams where oil and water need to be combined into a stable mixture. Without surfactants, these two phases would separate, leading to an unstable formulation.

Surfactants help create an emulsion by surrounding oil droplets and preventing them from coalescing, thereby promoting a uniform texture and consistency in the cream. This ensures that the product delivers its intended benefits effectively on application.

While surfactants are not primarily used as preservatives, thickeners, or for enhancing bioavailability, those roles may be addressed by different ingredients in a cream formulation. Therefore, the role of surfactants in emulsifying oil or water is essential for the stability and functionality of cream preparations.