FPGEE for National Association of Boards of Pharmacy (NABP) Practice Exam

What is the main advantage of low molecular weight heparin (LMWH) over standard heparin?

1. Requires more frequent administration

2. Higher risk of bleeding

3. Easy absorption

4. Higher incidence of allergic reactions

The correct answer is: Easy absorption

Low molecular weight heparin (LMWH) is preferred in many clinical situations due to its ease of absorption when administered subcutaneously, which is one of its main advantages. This characteristic results from the smaller size of LMWH particles compared to standard unfractionated heparin, allowing for more predictable pharmacokinetics and bioavailability. Due to its predictable response, LMWH often requires less intensive monitoring of anticoagulant effects. This reduces the need for frequent laboratory testing to monitor the anticoagulation levels, which is often necessary with standard heparin. Additionally, the ease of subcutaneous administration contributes to patient convenience and enhances compliance since patients can often self-administer LMWH, further supporting its widespread use in both inpatient and outpatient settings. In contrast, other options reflect disadvantages associated with LMWH or standard heparin; for example, the need for more frequent administration, a higher risk of bleeding, and potential allergic reactions, are not benefits associated with LMWH compared to standard heparin. Hence, the ease of absorption stands out as a significant advantage.