FPGEE for National Association of Boards of Pharmacy (NABP) Practice Exam

What neurological effect is commonly associated with carbamazepine?

1. Ataxia

2. Amnesia

3. Paralysis

4. Seizures

The correct answer is: Ataxia

Carbamazepine is an antiepileptic drug primarily used to treat seizures, but it is also effective for certain types of neuropathic pain and mood disorders. One of the neurological effects associated with the use of carbamazepine is ataxia, which refers to a lack of muscle control or coordination of voluntary movements. This can manifest as unsteady gait, difficulties with fine motor tasks, and general clumsiness. Ataxia is a well-documented side effect, particularly during the initiation of therapy or when the dose is increased. This is due to carbamazepine's impact on neuronal excitability and synaptic transmission, which can lead to disruption in the cerebellum’s ability to coordinate movements effectively. While the other options listed can be serious conditions related to neurological health, they are not directly common side effects of carbamazepine. For example, amnesia may occur in certain cases but is not a typical response to this medication. Paralysis is not a typical side effect linked to carbamazepine either, and seizures are, in fact, what the drug is used to treat. Hence, ataxia is the neurological effect that most closely correlates with the use of carbamazepine