FPGEE for National Association of Boards of Pharmacy (NABP) Practice Exam

Which drug is a common alternative to pseudoephedrine in many products?

1. Phenylephrine

2. Methamphetamine

3. Dextromethorphan

4. Phenobarbital

The correct answer is: Phenylephrine

Phenylephrine is commonly used as an alternative to pseudoephedrine in many over-the-counter (OTC) products, particularly those aimed at alleviating nasal congestion. Both pseudoephedrine and phenylephrine are decongestants, but they differ significantly in their chemical structures and mechanisms of action. Pseudoephedrine is notable for its effectiveness in relieving nasal congestion due to its ability to constrict blood vessels in the nasal passages. However, regulatory restrictions have limited its availability in some regions due to its potential misuse in the illicit manufacture of methamphetamine. In response to these restrictions, manufacturers often substitute pseudoephedrine with phenylephrine, which is less regulated. While phenylephrine can be found in many cold and allergy medications, its efficacy can sometimes be debated. Nonetheless, it remains a popular alternative choice in the formulation of various products, as many consumers seek options that do not require special handling or identification for purchase. The other options presented serve different purposes and are not substitutes for pseudoephedrine in treating nasal congestion. Methamphetamine is an illicit substance with no use as a legal medication for congestion, dextromethorphan is primarily used as a cough suppressant, and phenobarbital is a barbiturate used